Abstract
Introduction. Mitochondrial morphology and metabolism can have a decisive influence on energy metabolism and reproductive function in women. The objective of this study is to characterize the metabolic and energy metabolism processes in women of reproductive age and those in perimenopause. Methods. The study involved 100 women divided into two equal groups: women of reproductive age and women in perimenopause. Results. All participants had regular menstrual cycles. The duration of menopause in the second group was 1-3 years, with an onset age of 45 years. In total, 64% of the women in group 2 had neurohumoral abnormalities and obesity. Moderate to severe menopause symptoms were detected in 56% of women. Group 2 had reduced activity of mitochondrial enzymes in lymphocytes, such as succinate dehydrogenase and α-glycerophosphate dehydrogenase, while protein, glucose, and uric acid were above normal. Conclusion. This finding suggests that mitochondrial enzymes in group 2 become less active with age. At the end of the reproductive age, the intensity of the energy processes decreases. Cell energy metabolism remains an important area as further research, as this process can shift the timing of reproductive aging in women.
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