Ролята на атопията към фунги в патогенезата на хроничния риносинуит

Abstract

Aim: The aim of this study was to identify the different fungi: Alternaria, Aspergillus, Fusarium, Penicillium, Mucor and Rhizopus through skin prick test in chronic rhinosinusitis (CRS) patients and to correlate their participation in pathogenesis of chronic inflammatory nose mucous membrane changes. Material and methods: Two groups of subjects were included: - A control group of 25 normal individuals (14 males and 11 females from 20 to 65 year old) - A patient group of I 00 adult CRS patients (55 males and 45 females from 20 to 65 year old) was enrolled throughout three years. The patient group is separated on two subgroups: CRS without nasal polyposis (NP) - 70 patients and CRS with NP (30 patients). Chronic rhinosinusitis was diagnosed based on medical history, physical exam and CT scan data. Skin prick test to fungal allergens was performed with all patients and healthy controls. Results: I. Normal control group: Skin prick test was positive in 2 (8%) patients. 2. Patient group: 38 (38%) of them were positive to allergens of fungal origin. CRS without NP was positive in 30 (42,86%) patients. CRS with NP was positive in 8 (26,67%) patients. Discussion: Recently many discussions arise concerning the role of fungi in CRS. Positive skin prick test to one or more fungal allergens in 38% of CRS patients proves the high frequency and role of fungi in chronic inflammation pathogenesis. Profound analyses are necessary concerning role and frequency of Dcmatiaceous family and Aspcrgillus fungi in the pathologic process of chronic nasal cavities inflammation.