Abstract
Lowering or full stopping of the skeletal muscles contraction activities leads to atrophy of the muscle fibers and loss of performance. These changes affect the life quality of people who for one or another reason are faced with a limited ability to move. Among the key triggers of events in regulation responsible for the changes due to low muscle activity (disuse) is disturbance of calcium homeostasis and consequent build up of Ca deposits in the fiber myoplasm. The review is devoted to analysis of causes for Ca homeostasis disturbance, including macroergic phosphate accumulation, by the muscle disuse. The authors hypothesize a mechanism regulating the SERCA and IP3-receptors and their role in myoplasmic Ca deposit during functional unloading of muscles.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
