Кросскорреляционный и когерентный анализ электрокортикограмм крыс, перенесших черепно-мозговую травму

Abstract

Traumatic brain injury (TBI) is a leading cause of disability and mortality among young population both in Russian Federation and abroad. The development of adequate and reproducible models of TBI in laboratory animals as well as precise methods for assessment of neurological disorders degree will optimize investigation of new effective neuroprotective drugs. Aim of the study: to perform the comparative crosscorrelation and coherent analysis of ECOG signal in non-injured rats and rats with TBI rats. The open penetrating brain injury was modeled following the craniotomy over the motor cortex of the left hemisphere by controlled cortical impact injury method (CCI). The recording nichrome ECoG electrodes were implanted bilaterally in the primary and secondary motor cortex areas and also in the area of primary somatosensory cortex (over the hippocampus). ECoG recordings were performed on the 3rd and 7th day after the operation in condition of the home cage at resting state. Crosscorrelation analysis comprised the calculation of crosscorrelation coefficient, mean frequency and maximum span of crosscorrelation function (CCF). Also the calculated mean coherence power of delta-, tetha-, alpha- and beta-rhythms. Unilateral traumatic damage of motor cortex and near situated brain areas lead to disturbances of inter- and intrahemispheric connections, these changes are recorded not only in the damaged area, but also in the remote areas of the cortex on the 3rd and 7th day after the injury.