Abstract
Aim. To improve the effectiveness of the therapy in patients with infiltrative and suppurative forms of zoonotic trichophytosis (ZT) immune modulator «Imunofan» was used. Matherial and method. Changes in levels of main lymphocyte subpopulations and the accumulation in blood cell cultures stimulated with pathogen antigens of cytokines — Interleukin 2 (IL-2) and Interferon gamma (IFN-γ) — have been studied. Results. There have been changes of lymphocyte subpopulations that are typical for the formation of cell-mediated immunity to dermatophytes (CMID) with concomitant stimulation of IL-2 and IFN-γ synthesis. In the course of treatment IL-2 production after short increase reduces, and IFN-γ production grows until the convalescence and CMID formation. Conclusion. Combined treatment of ZT with «Imunofan» intensifies signs of CMID with increasing IL-2 and IFN-γ production. At once the regression of inflammation symptoms in the foci occurs earlier than in control groups.
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