Значение морфометрических характеристик заднего сегмента глаза при использовании ПИТРС-терапии

Abstract

It is known that, along with other manifestations of multiple sclerosis (MS), the neurodegenerative process is manifested by optic neuropathy. Therefore, there is no doubt about the importance of analyzing changes in the thickness of the peripapillary nerve fibers, the ganglionic and internal plexiform layers of the retina, and the choroid during the dynamic observation and treatment of patients with MS with disease modifying therapy (DMT). Purpose. To assess the condition of the posterior segment of the eye in patients with optic neuropathy in MS during therapy with 1st and 2nd generation drugs of DMT with the combined use of neuroimaging methods of examination. Material and methods. The retina and optic nerve were examined by optical coherence tomography (OCT) in 68 patients with multiple sclerosis, divided depending on the type of therapy received. Results. Significant differences in the morphometric characteristics of the structures of the posterior segment of the eye were obtained against the background of DMT of the 1st and 2nd generations. Conclusion. The analysis of the parameters of the structures of the posterior segment of the eye, obtained using OCT, is a clinically important and informative approach for dynamic observation, determination of the effectiveness of drugs that change the course of multiple sclerosis and the choice of treatment regimens. Key words: disease modifying therapy (DMT), optical coherence tomography, multiple sclerosis.