Особенности соматосенсорных вызванных потенциалов у крыс после черепно-мозговой травмы

Abstract

The analysis of somatosensory evoked potentials (SSEP) curves was performed in rats 7 days after traumatic brain injury. The responses of the primary and secondary motor cortex were evoked by electrical stimulation of sciatic, median and trigeminal nerves. For each of the stimulated nerves the latencies and amplitudes of N1, P2, N2, P3 и N3 components were analyzed. Also, the durations and amplitudes of peak intervals were calculated. It is shown that unilateral traumatic damage of motor cortex and underlying areas does not cause significant decrease of peaks number on the SSEP curves, however, in some animals, there was a lack of early responses in the traumatized area ipsilaterally situated to the stimulation. In comparison with intact rats the traumatized animals had decreased amplitude of short-latency (N1, P2), and long-latency (N2, P2, N3) responses, and also prolonged latency of early responses and shortened of late. Such changes were observed not only in the traumatized area but in the intact hemisphere. These findings suggest that the model of controlled cortical impact injury has many electrophysiological similarities with injuries observed in patients in clinical practice.