Abstract
The properties of polymers are substantially determined by their molecular mass and molecular mass distribution. At the same time, the average molecular mass of the polymers does not characterize them complete enough, particularly it does not describe the properties of the polymers of special purpose, which are produced for drug delivery and drug release. In this case the accurate assessment of the properties of polymers is especially needed. The article deals with the research of the composition of fractions and functional homogeneity of new amphiphilic copolyesters. Fluorescein-containing amphiphilic copolyesters of N-acyl derivatives of glutamic acid and polyether diols, which form self-stabilized dispersions in aqueous media can be considered as promising multifunctional polymers and may be used in biomedicine.The molecular mass fractionation of copolyesters was carried out with the use of dialysis. The obtained polymers and their fractions were analyzed by exclusion chromatography and functional analysis, the surface tension was determined.A detailed molecular mass distribution of copolyesters was obtained byusing the efficient exclusion chromatography, as well as due to the rather high mass of the monomers. The content of individual fractions, their functionality and colloid-chemical properties were quantitatively compared. It was shown that despite the different molecular mass the individual fractions of a copolyester were homogeneous with identical properties. This allowed us to describe such copolyesters as the good base for the creation of drug delivery systems and nanodiagnostics.
Highlights
The properties of polymers are substantially determined by their molecular mass and molecular mass distribution
Investigations of the production of a copolyester by the irreversible copolycondensation method using the Steglich esterification reaction showed that this method has ample opportunity to construct copolyester macromolecules of a definite structure and functionality [19,20,21]
According to the mentioned reaction, we obtained and characterized a number of polymer products, which differ by the substituent R- in Nsubstituted glutamic acid, mass of polyoxyethylene diol (PEG 600, 1000) and the content of fluorescein
Summary
Creating drug delivery systems based on systems, the molecular mass of the polymer is nanoscale particles is an urgent task at the important because it greatly affects the formation current stage of the development of chemistry of nanoparticles, their stability over time and [1,2,3,4,5]. Molecular mass are present in the final product.It. Analysis of the studies in the field of drug may have different properties depending on the delivery systems has shown that the main focus is method of production. Analysis of the studies in the field of drug may have different properties depending on the delivery systems has shown that the main focus is method of production In this case, it may be diffion amphiphilic copolymers, which make it cult to predict the behavior of the polymer-based possible to create aggregate-resistant nano- and drug accurately in the body [17]. The content of the dialysis bag was evaporated and the main fraction of copolyester was obtained
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