Персонифицированный подход к ранней диагностике молниеносной формы острого некротического панкреатита

Abstract

The aim of the research. To develop an individual approach to diagnosis of the fulminant form of acute pancreatitis based on laboratory and instrumental research methods. Material and methods. Th e retrospective phase of the study (2016-2018) enrolled 31 patients diagnosed with severe acute pancreatitis (SAP) – the control group. These patients underwent analysis of the results of surgical treatment in order to determine the factors of adverse outcome of the disease. On this basis, a special category of patients was identified, requiring changes in existing diagnostics and surgical tactics depending on the course of the disease. At the prospective stage (2018-2020), a total of 27 patients diagnosed with SAP (the main group) were included. Results. For these patients, we introduced an individualised approach to diagnosis and performed comparative analysis of its effectiveness. The comparative analysis of both groups was carried out based on the main indicators of the patients’ initial condition. Th e distribution of patients between the compared groups had no statistical difference in the gender composition (χ 2 = 0.141, p> 0.05). Th e age of patients ranged from 24 to 83 years. The average age was 44.3 ± 12.6 years in the control group and 43.7 ± 14.4 years in the main group (Student’s t-test = 0.7, p > 0.05). No statistically significant differences were revealed between groups in each age category. Conclusion. In our study on patients with fulminant progression, we emphasised a combination of additional attributes. Th e analysis has revealed statistically significant differences between the “fulminant” and the “typical” progression in the occurrence rate of the combination of attributes.