توليف وتوصيف قواعد شيف الجديدة للكيتوزان ودراسة نشاطها المضاد للميكروبات

Abstract

Biopolymers and their derivatives have a wide range applications due to their biodegradability, low toxicity, and biocompatibility. The current study aimed to develop and characterize the unique Schiff ,s chitosan bases by conjugation the chitosan with different aldehydes under acidic conditions to form Schiff ,s chitosan bases which reacted with a plant extract derivative (capsaicin) to get new Schiff ,s derivatives. The resulting compounds were diagnosed by using fourier transform infrared (FT-IR), as well as nuclear magnetic resonance(1H-NMR). The biological activity of the new derivatives was studied to know its importance and its applications in the medical fields, where the antibacterial activity of positive-gram bacteria, negative- gram bacteria and fungi was tested. The results showed an increase of the substituted chitosan antibacterial activity against both positive-gram and negative- gram bacteria due to its high capsaicin content, which is highly effective against bacteria and fungi.