ВЫРАЖЕННОСТЬ ДЕПРЕССИИ И АНДРОГЕННОГО ДЕФИЦИТА У МУЖЧИН МОЛОДОГО ВОЗРАСТА С ИМПST НА ЭКГ С УЧЕТОМ АНГИОГРАФИЧЕСКОЙ КАРТИНЫ

Abstract

Abstract. Introduction. In young age, due to low evidence and gender inequality, non-obstructive acute coronary syndrome including slow blood flow is in priority. Aim. The aim was to evaluate severity of depression and androgen deficiency in young men with ST segment elevation myocardial infarction due to atherothrombosis and slow flow phenomenon.Material and methods. 99 men aged 25 to 44 years, were observed: 60 patients with ST segment elevation myocardial infarction and slow flow phenomenon, 39 patients with infarction due to coronary artery occlusion. The study did not include patients with body mass index more than 35 kg/m2, diabetes, valve diseases, arrhythmias, conductive disorders, previous history of acute coronary syndrome and pre-hospital fibrinolysis, surgery on pelvic organs and scrotum, prostate cancer, congenital hypogonadism, taking steroids, chronic kidney and liver diseases with impaired function, refusal to participate. Subjective signs of androgen deficiency and erectile dysfunction were analyzed, as well as presence and severity of depression according to Beck's Depression Inventory. Serum levels of prolactin, testosterone, luteinizing hormone, cortisol, sex steroid-binding globulin and free testosterone were measured.Results and discussion. Slow flow phenomenon patients had higher free testosterone and lower serum cortisol concentrations (p=0.04 and p=0.02). In the first group, mild erectile disfunction prevailed (35%), it was absent in 23.3% of respondents, severe disorders were noted in 13.3% of cases. In the second group, erectile disfunction was absent in 23.3%, and 36.7% of respondents had mild symptoms. 23.3% had moderate erectile disfunction. Males with severe and moderate symptoms of androgen deficiency prevailed in the second group. The absence of depression was found in 18.3% and 23.3% in both groups. Conclusion. High prevalence of depression in young men with type 1 myocardial infarction and with slow coronary blood flow has been established. Differences were found in levels of cortisol and free testosterone in groups, which did not correlate with subjective severity of erectile dysfunction symptoms. The results suggest that there is a relationship between estimated parameters, angiogram, and severity of myocardial damage in case of myocardial infarction in young men. To confirm this hypothesis, a prospective follow-up with assessment of one-year survival is required.