Abstract
As part of the study of polymer systems based on a chlorine photosensitizer, photodithazine (PD), photodynamic therapy was used to study the fluorescence and Rayleigh scattering spectra upon excitation at wavelengths lambdaex = 260, 280, 400, and 450 nm. Non-toxic water-soluble poly-N-vinylpyrrolidone (PVP) and vegetable polysaccharide were used as the polymer. sodium alginate (SA). The data of the PD-SA dual system is characterized by variability of characteristics depending on the preparation conditions, while in the PD-SA-PVP ternary complex, there is a favorable mutual influence of two SA and PVP polymers on the PD molecule, due to the creation of a local microenvironment of the active center PD with increased polarity . It was shown that the introduction of tryptophan (Trp), used as a substrate in model photo-oxidation processes, when testing the effectiveness of photosensitizers in the generation of singlet oxygen, does not significantly change the fluorescence parameters of the PD-SA-PVP complex.
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