Особенности системы плазменного гемостаза у пациентов с новой коронавирусной инфекцией COVID-19

Abstract

Aim To investigate plasma hemostasis in patients with different levels of COVID-19 severity Materials and methods The study included 46 patients with confirmed COVID-19, who were stratified into four groups based on disease severity as mild (1), moderate (2), severe (3), and critically severe (4) Laboratory investigations included APTT, Quick's prothrombin time, concentration of D-dimer, fibrinogen, ATIII, and platelet count Results D-dimer concentration >450 ng/ml was found in 100% of patients increasing from 973 (545–1635) ng/ml in group 1 to 13513 (7627–22512) ng/ml in group 4 (p 3633 ng/ml (specificity 92 3%, sensitivity 100%, AUC 0 94, p <0 001, positive predictive value 99 1%, and negative predictive value 100%) and ATIII <70 8% (specificity 70%, sensitivity 82 6%, AUC 0 85, p <0 001, positive predictive value 30 5%, and negative predictive value 96 1%) Conclusion The levels of D-dimer, fibrinogen, and ATIII were found to be associated with the severity of COVID-19