Abstract
Antimicrobial therapy is a significant element of modern medical and pharmaceutical practice. To create more effective medicines the researches are carried out among different classes of organic substances. One of the key strategies in this field is combination of several pharmacophores in a single molecule.
 
 In this aspect, the authors´ attention was attracted derivatives xantina, with a wide range of paid activity, and the large variability of the possibility of chemical modification.
 
 Objects of the study were derivatives of 3-benzyl-8-methylxanthinyl-7-acetic acid, synthesized by authors´ group previously. Antibacterial properties of these compounds were studied on Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and antifungal activity on Candida albicans.
 
 It was found that the most active against Staphylococcus aureus compound was substance A-18, which according to this indicator significantly exceeded the Ampicillin. Compounds A-4, A-9, A-ll, A-13, A-19 by antistaphylococcal activity are not inferior to the Am-picillin. Ylidenhydrazide A-16 and S-substituted triazolylmethylxanthines A-22 and A-23 - surpassed it. It was also found that hydra-zide A-3, ylidenhydrazides A-6, A-ll - A-14 and A-17 showed fungistatic properties comparable to the Nystatin.
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