МЕТАБОЛИЗМ БЕЛКОВ В ОРГАНИЗМЕ РАСТУЩИХ БОРОВКОВ ПРИ ДОБАВЛЕНИИ В РАЦИОН 20-ГИДРОКСИЭКДИЗОНА

Abstract

One of the approaches to the creation of biologically active additives in pig nutrition can be the use of phytopreparations, in par-ticular, 20-hydroxyecdysone (20-GE), which regulates protein metabolism in piglets. The aim of this work is to assess the effect of 20-GE on the metabolism of proteins in the body and to measure their turnover in grow-ing boars. The experiment was carried out on boars (♂ Danish Yorkshire × ♀ Danish Landrace) from 60 to 120 days of age. At the age of 60 days, boars were divided into 2 groups: control and experimental, fed with feed with a content (g / kg) of crude protein 158.7, lysine 7.7, threonine 4.8, methionine 4.6, exchange energy (EE) 12.7 MJ / kg. The ratio of the first limiting amino acid lysine to EE was 61%. The boars of the experimental group were injected with 20-GE at a dose of 1.6 mg / kg of body weight. In boars of the experimental group, compared with the con-trol, there was a decrease in urinary nitrogen excretion (by 26.8%, P≤0.05). Nitrogen re-tention was higher in boars of the experi-mental group by 19.0% (P≤0.001) compared to the control. The results of studies on pro-tein turnover obtained using a stable isotope indicate that the anabolic effect of 20-GE isdetermined by an increase in the rate of pro-tein synthesis at the same rates of their deg-radation, nitrogen flow against the back-ground of a decrease in its endogenous loss-es. 20-GE by activating a signal through protein kinase B provides an increase in bio-synthetic processes at the stage of transla-tion. It was concluded that the use of 20-GE in boars cultivation increases the efficiency of using amino acids for the synthesis and deposition of proteins in the body.