비만유도 흰쥐에서 반복적 절식과 운동부하가 골격근내 세포사멸 및 당수송체에 미치는 영향

Abstract

The purpose of this study is to rely on an extremely limited diet weight loss is a heavy negative effect on intracellular lipid metabolism and reduced insulin secretion induced by inhibition of intracellular homeostasis was thought to be a factor. For therefore investigate the physiological effects of exercise was conducted. Twenty-two Sparague Dawley rats were divided into 4 groups as follows: high fat diet group(HF, n=8), high fat diet with repeated fasting and refeeding group (HFFR, n=8), repeated fasting and refeeding and exercise after high fat diet group(HFFR＋EX, n=8) and pair feding to HFFR group (HFFR＋PF, n=8). Diet-induced obesity was fed a high-fat for 8 weeks, and obesity intervention was drived by treadmill running exercise program or food intake restriction. As a result, through repeated food restriction were decreased body weight, body fat reduction and improvement blood lipid profiles. And when combined exercise training was confirmed this trend more pronounced(p.05). Furthermore, the expression of GLUT4 expression in skeletal muscle decreases due to restricted movement, but it was confirmed to be increased through exercise training. Expression of apoptosis-related CHOP mRNA were combined exercise and dietary restriction significantly decreased. In conclusion, the results of this study, including obesity, diabetes and other metabolic syndrome disorders in a course of treatment being carried out mainly in the dietary restriction and exercise programs to the specific direction is expected to be present.