Abstract
This study shows the effect of long-term treadmill exercise on the expression level of amyloid beta protein and C-terminal peptide fragment of amyloid precursor protein (APP-C99), cognitive function and diabetes which has been known that highly related to Alzheimer’s disease.BR Comparing to Alzheimer’s disease animal model group, the group performed treadmill exercise for 16 weeks has shown the decrease of Aβ and APP-C99 expression and the increase of Aβ-induced intracellular downstream proteins including Akt, p-Akt, p85, p-p85, but There was no difference between groups GSK3β and p-GSK3β. Also, it demonstrated that treadmill exercise ameliorates decreased insulin response and insulin-related proteins, such as IR, p-IR, IDE, and GLUT-1 and increases the blood glucose level.BR Searching for the effects of exercising on the cognition of APPsw transgenic mouse model, water maze test was performed and the exercise group showed improvement of cognition. It could be considered that long-term treadmill exercise reduces the accumulation of amyloid beta protein through activating the intracellular signal of insulin. Furthermore, cognitive function was enhanced.BR Therefore, long-term exercise prevents the cause of Alzheimer’s disease and alleviates the symptoms.
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