Abstract
The aim of the research. To develop a method for predicting the degree of changes in the gallbladder wall in acute cholecystitis. Material and methods. A single-stage study was performed on 105 patients with an established diagnosis of acute cholecystitis who underwent laparoscopic cholecystectomy, comparable in age, gender and concomitant pathology. Upon admission to the hospital, the activity of creatine phosphokinase (CPK), lactate dehydrogenase (LDH), gamma-glutamiltranspeptidase (GGTP) and alkaline phosphatase was determined through the kinetic colorimetric method. Statistical processing of the obtained results was carried out using the SPSS Statistics 7.0 program in compliance with the principles of statistical analysis adopted for research in biology and medicine. Results. In patients with acute destructive cholecystitis, mean CPK values were 302.2±32.5 U/l (p <0.05) and LDH - 318.3±29.4 U/l (p <0.05), which is higher than the values obtained in the group with acute non-destructive cholecystitis: CPK – 168.7±18.3 U/l (p <0.05) and LDH – 282.6±18.3 U/l (p <0.05). Along with this, a direct correlation was revealed between an increase in the concentration of CPK, LDH and the degree of destructive process in the gallbladder wall. At the same time, in patients with non-destructive cholecystitis, mean values were 340±116.9 U/l (p <0.05) for GGTP and 160.3±34.2 U/l (p <0.05) for SCHF, which exceeds these values in the group of patients with acute destructive cholecystitis: GGTP was 70.5±18.5 U/l (p <0.05), and SCHF was 93.5±16.5 U/l (p <0.05). With progression of destructive processes in the gallbladder wall, the concentration of GGTP and alkaline phosphatase decreases.
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