ВЛИЯНИЕ БИОЛОГИЧЕСКОГО СТИМУЛЯТОРА НУКЛЕОСТИМ НА ЦЕНТРАЛЬНЫЕ ОРГАНЫ ИММУНИТЕТА У ЦЫПЛЯТ-БРОЙЛЕРОВ

Abstract

Poultry farming is one of the most important dynamically developing branches of the agro-industrial complex, providing the population with fullfledged food products. It is necessary to search for new useful biological substances to increase the efficiency of the industry. At the same time, biologically active substances must be not only highly effective but also harmless to animals and humans. To date, significant experimental data on the use of biological stimulants in poultry and animal husbandry have been accumulated. The research aimed to study the influence of the biological stimulator Nucleostim on the development of the thymus and its clinical and morphological structure. 100 ROSS 308 cross broiler chickens were used for the research. Experimental and control groups of animals were kept in the same conditions on a unique, balanced diet with free access to water. In the course of the research, it was found that in 3 experimental groups, the mass of internal organs of broiler chickens is greater than in the control group. The most significant increase in organs was observed in chickens receiving Nucleostim at a dose (10 g/kg of feed). The use of the biological stimulator Nucleostim as a top dressing in broiler chickens preserves the structure of the thymus, with clear visualization and differentiation of the cortical layer and brain matter, increases the mitotic activity of thymocytes, improves blood supply to the organ. As a result of research, it was found that Nucleostim has an immunomodulatory effect, which is expressed in hypertrophy and hyperplasia of the thymus, increasing the number of CD 68 macrophages, slowing down the thymus involution processes in broiler chickens.