Применение противовирусной терапии в лечении хронических фаринготонзиллитов при персистирующей герпетической инфекции

Abstract

The article presents the data of our own studies of the role of herpesviruses (HV), more specifically of Epstein–Barr virus (EBV), cytomegalovirus (CMV) and human herpes virus type 6 (HHV-6), in the etiopathogenesis of chronic pharyngotonsillitis (CPT). For the selection of patients with CPT the «classification trees» method was used. Herpes infection of the oropharynx on the background in the examined patients was determined by the avidity index of Ig class G for EBV and CMV, the level of Ig class G for HHV-6, and the viral load (VL) test of the pharyngeal mucosa of these viruses using the polymerase chain reaction in the real time mode (PCR Real-time). An original treatment regimen of the combination of three groups of antiviral drugs for these patients has been proposed. An assessment of the efficacy of antiviral therapy in CPT with herpes infection on the background in the annual period was assessed using the following parameters: comparison of subjective data on the prevalence of patient complaints in the group with antiviral therapy (main group) and without antiviral therapy (control group), comparison of objective data of the status localis, control identification of virus particles with Real-time PCR in these groups.