Abstract
Central acetylcholinesterase (AChE) inhibitors belong to the basic drugs for the treatment of dementia. The article discusses the basic principles of AChE in clinical practice. Particular attention is paid to the measures of evaluation concerning the efficacy of drugs (given the properly titrated dose), to the improvement of drug tolerability, in particular, through the prescription of correctors (drugs that reduce the severity of AChE adverse events), and a balanced approach to the AChE prescription, given the absolute and relative contraindications and polypragmasia characteristic of elderly patients with dementia. The article also emphasizes the importance of informing relatives and caregivers about the AChE mechanism of action to form an adequate level of expectations and rational use of pharmacotherapy. The article lists the situations in which the AChE cancellation is justified even if there is a therapy effect. KEYWORDS: dementia, Alzheimer’s disease, cognitive impairment, basic therapy, cholinesterase inhibitors, dose titration, donepezil. FOR CITATION: Chebotareva A.D., Levin O.S. Ten principles of using the cholinesterase inhibitors in the treatment of dementia in clinical practice. Russian Medical Inquiry. 2022;6(10):576–579 (in Russ.). DOI: 10.32364/2587-6821-2022-6-10-576-579.
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