ПРЕВЕНТИВНОЕ ЛЕЧЕНИЕ ТУБЕРКУЛЕЗА У ДЕТЕЙ ИЗ КОНТАКТА С ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТЬЮ МИКОБАКТЕРИЙ

Abstract

The aim of the study was to study the clinical and immunological efficacy of meglumine acrydon acetate immunomodulator in the preventive treatment of tuberculosis in children from tuberculous contact with drug resistance of mycobacterium tuberculosis (MBT). Material and methods. The evaluation of the effectiveness of the immunomodulator was performed in 34 children from contact with drug resistant tuberculosis (LUTB) in comparison with the effectiveness of traditional chemoprophylaxis using isoniazid in 40 children. Results. Both methods of preventing tuberculosis in children equally reduce the tuberculin sensitivity, and meglumine acridon acetate also prevents a hyperergic reaction to tuberculin. The immunomodulatory effect of meglumine acridon acetate, manifested by the increase in the level of T cells, activation of the phagocytic activity of neutrophils and their bactericidal activity is very important for the prevention of tuberculosis in children from TB contact. Conclusions. In conditions of contact of children with patients who release drug-resistant MBT, when chemoprophylaxis with isoniazid does not have the desired effect, an alternative method of preventing tuberculosis is the use of meglumine acridon acetate.