ИЗУЧЕНИЕ ХИМИЧЕСКОГО СОСТАВА И АНТИОКСИДАНТНОЙ АКТИВНОСТИ СУХОГО ЭКСТРАКТА ТРАВЫ ПОСКОННИКА КОНОПЛЯНОГО

Abstract

The article presents the results of a study of a polyphenolic extract of the herb Eupatorium cannabinum L., which grows on the territory of the Krasnodar Territory. The aim of the study was to conduct a phytochemical analysis of the BAS of a dry extract of Eupatorium cannabinum L. and determination of its antioxidant activity. Thus, as a result of the conducted studies, it was found that a diverse composition of phenolic compounds is identified in the dry extract of Eupatorium cannabinum L., among which the presence of rutin, quercetin salicylic, chlorogenic, caffeic, ferulic, π-coumaric and gallic acids was revealed. It was found that the content of phenolic carboxylic acids in the dry extract of Eupatorium cannabinum L. averaged 15.10%, flavonoids – 4.34%. The results of the studies conducted on the in vitro model system revealed the ability of the dry extract of Eupatorium cannabinum L. reduce the accumulation of Fe2+-induced POL products, which indicates the presence of direct antioxidant action. The mechanism of action of the resulting extraction product on the one hand may be related to the ability of phenolic compounds that make up the dry extract to act as free radical traps and restore reactive oxygen species, on the other hand, the resulting extract can act as chelators of Fe2+ ions, which significantly reduces the rate of free radical processes. The obtained data complement the previously discovered information about the antimicrobial effect of the dry extract of the cannabis herb and allow us to predict the potential effectiveness of the use of drugs based on it for the treatment of infectious and inflammatory skin diseases due to the presence of combined antimicrobial and antioxidant effects.