Abstract
Stroke takes the second place among all causes for cardiovascular death and the first place in mortality and disability among other nervous system diseases. Atrial fibrillation (AF) is presently is a commonly recognized, independent risk factor for ischemic stroke, which fivefold increases the risk of an unfavorable outcome. Prevention of stroke is a complicated medical and social challenge. To study AF prevalence among patients with stroke/transient ischemic attack (TIA) who had received an anticoagulant therapy before hospitalization. A retrospective analysis of case reports was performed for patients diagnosed with acute cerebrovascular disease and TIA who had received a therapy from January, 2013 through December, 2015 (n=7921). From these case reports, 849 case reports of patients with concurrent AF were selected. In patients with stroke/TIA, the AF incidence was 10.72%. Risk assessment using the CHA2DS2‑VASc scale showed that the percentage of low-risk patients (score 0) was 0.8%, intermediate risk patients (score 1) - 5.3%, and high-risk patients (score ≥2) - 93.8%; 4.7% of patients with AF received preventive therapy for thromboembolic complications. The death rate of patients with AF and stroke/TIA was 15.78% whereas in-hospital death rate of patients without AF was 7.01%. Therefore, AF is a statistically significant risk factor of in-hospital mortality for patients with stroke/TIA (OR=2.485; 95% CI: 2.023-3.053; p.
Highlights
Stroke takes the second place among all causes for cardiovascular death and the first place in mortality and disability among other nervous system diseases
С учетом возможного бессимптомного течения пароксизмальной формы фибрилляция предсердий (ФП) истинная ее распространенность среди пациентов с инсультом остается зачастую недооцененной, что особенно актуально в случаях криптогенных ишемических инсультов
Risk Factor, Pattern, Etiology and Outcome in Ischemic Stroke Patients with Cancer: A Nested Case-Control Study
Summary
Stroke takes the second place among all causes for cardiovascular death and the first place in mortality and disability among other nervous system diseases. Риск развития ишемического инсульта у пациентов с ФП является неоднородным в различных возрастных группах: от 1,5 % в группе лиц 50–59 лет до 23,5 % в группе 80–89 лет [8]. Дополнительными ФР развития инсульта у пациентов с ФП, помимо возраста, служат АГ, СД 2 типа, СН, ранее перенесенные инсульт / транзиторная ишемическая атака (ТИА), заболевания периферических сосудов и женский пол [11,12,13]. Для всех пациентов с ФП были рассчитаны риск развития тромбоэмболических осложнений по шкале CHA2DS2‐VASc и риск серьезных кровотечений по шкале HAS-BLED [27] при расчете не учитывались текущие ОНМК и ТИА в целях определения показаний к антикоагулянтной терапии до инцидентного события и анализа проводимой профилактики.
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