Опыт применения расчета объемной фракции интерстициального коллагена у больных артериальной гипертонией

Abstract

The aim of the research is to optimize the assessment of collagen volumetric fraction in patients with stage 1 and 2 hypertensions. Material and methods. In total 39 patients with arterial hypertension took part in the study. Group 1 included patients (n = 13) with stage 1 hypertension, the second group included patients with stage 2 hypertension (n = 26). To verify structural changes in the left ventricle, all subjects underwent comprehensive examination, including history taking, anthropometric data taking, ECG study with the calculation of general QRS (mm) as a total indicator of R wave amplitude in 12 electrocardiographic leads, and echocardiography according to standard technique. Statistical analysis, based on the data obtained, was carried out using SPSS soft ware package. Furthermore, there was comparison of collagen volumetric fraction calculation (СVFC) according to the method of J. Shirani et al. (1992), and by our own formula based on nonlinear regression equation. Results. When calculating СVFC in accordance with the formula of J. Shirani et al. (1992), СVFC values (%) in the 1st group of subjects were 8.48 [5.5; 9.7]; in the 2nd group they were 11.16 [0.5; 1.7], (U = 51.0, p = 0.45). When studying groups СVFC in accordance with the alternative formula, more statistically signifi cant diff erences were observed: СVFC values in the 1st group were 23.5 [21.4; 30.4], in the 2nd group - 29.5 [25.5; 35.7] (U = 105.0, p = 0.049). Conclusion. The developed method for calculating collagen volumetric fraction is more pathogenetically suffi cient. Th is makes it possible to determine this indicator more accurately for identifying a group of patients suffering from stage 1 and 2 hypertension, with a high risk of heart failure development for its wide use in clinical practice to monitor them more frequent and to correct their therapy.