ВАЗОМОТОРНЫЕ РЕАКЦИИ НА ЛОКАЛЬНОЕ ОХЛАЖДЕНИЕ У МОЛОДЫХ ЛИЦ С НИКОТИНОВОЙ ЗАВИСИМОСТЬЮ

Abstract

Tobacco smoking, as a harmful individual habit, aggravates the negative environmental effects on health in people living in the northern regions of Russia, by increasing the incidence of diseases of the cardiovascular and respiratory systems, and oncological diseases. This study was aimed at elucidating the vasomotor reactions on local cooling in young people with nicotine addiction. Materials and methods. Twenty four practically healthy people (13 m, 11 f) aged 18-27 years were enrolled to the study. Of these, 16 subjects with initial stage of nicotine addiction formed the study group, and 8 non-smoking subjects served as a reference group. The degree of nicotine addiction was assessed with the Fagerstrom test and the smoking index. The local cold test (LCT) was used to study vasomotor reactions. The autonomous regulation was estimated by analyzing the time- and frequency-domain characteristics of heart rate variability (HRV). Results. In the group with nicotine addiction, increased cold-induced vasoconstriction was revealed from the dynamics of the hand skin temperature during LCT. Also, this group mwas characterized by decreased vagotonia seen as lower values of time- (SDNN, RMSSD, pNN50 and CV) and frequency- domain (TP, HF and LF) parameters of HRV. The functional test with deep controlled breathing revealed in this group lower reactivity of neurogenic mechanisms of heart rate control. Among subjects with higher number of cigarette consumption, HRV changes which corresponded with adaptation disorders were more notable. Conclusion. Individuals with initial degree of nicotine addiction were characterized by the impaired reactivity of the central and peripheral parts of the circulatory system what means lower health capacity of the organism. Increased vascular reactivity during LCT, as well as the impaired adaptation seen with HRV analysis, could serve as early indicators of the systemic effects of tobacco smoking.