Abstract
Obesity is the most common health problem in developed countries and is considered a significant risk factor for many major human diseases. This study aimed to evaluate the inhibitory effect of lactic acid bacteria isolated from the human vagina and shellfish on adipocyte differentiation in 3T3-L1 preadipocytes. The activity of separated 221 strains on pancrease lipase was measured and 15 strains were first screened. The level of adipogenesis of these strains in the 3T3-L1 cells was measured by Oil Red O staining assay. Five strains including Lactobacillus plantarum (2 strains) and L. fermentum (3 strains) showed good adipocyte differentiation inhibitory activity. Also, the selected strains were resistant to bile acid up to 3% and their autoaggregation rates were as high as 50%. These Lactobacillus strains with probiotics potential may be useful for prevention or treatment of obesity, but further in vitro and in vivo studies on these strains are still required.
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