Abstract
Trauma injuries account for high mortality and disability in the cohort of the employable population. Pulmonary infectious complications in those injured with multiple traumas contribute the most to mortality of such patients. The article describes risk factors, causative agents, pathologic physiology and specific features of diagnostics of nosocomial pneumonia in those with multiple traumas. Special attention is paid to study of state and variants of the immune response to multiple trauma and related issues on using polymorphism of genes controlling the release of certain cytokines in order to improve diagnostics and prognosis of the course and outcome of nosocomial pneumonia in this group of patients.
Highlights
Trauma injuries account for high mortality and disability in the cohort of the employable population
Pulmonary infectious complications in those injured with multiple traumas contribute the most to mortality of such patients
Special attention is paid to study of state and variants of the immune response to multiple trauma and related issues on using polymorphism of genes controlling the release of certain cytokines in order to improve diagnostics and prognosis of the course and outcome of nosocomial pneumonia in this group of patients
Summary
Trauma injuries account for high mortality and disability in the cohort of the employable population. Частота развития пневмонии у пострадавших при политравме может достигать 45–50%, при этом данный диагноз в 90% случаев устанавливают в период 3–10-х сут с момента получения травмы [2, 9]. В связи с вышеуказанными трудностями традиционной диагностики нозокомиальной пневмонии у пострадавших при политравме в последнее время значительное внимание стало уделяться изучению тонких молекулярно-генетических механизмов данного патологического процесса.
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