Abstract
The problem of mixed viral infections in children with herpes-induced immunosuppression has not been sufficiently studied. The causal therapy for enterovirus infections is still being developed; it is not widely used in the adult population and not used at all in children. Objective. To evaluate the efficacy of Viferon® for the treatment of enterovirus meningitis in preschool children with herpesvirus infection. Patients and methods. This study included two groups of children aged 3 to 7 years (30 children in each) with clinical manifestations of enterovirus meningitis. Patients in one group had no markers of herpesvirus infection, whereas patients in the second group had markers of herpesvirus infection (virus persistence). Children in the second group received recombinant human interferon a-2b (Viferon®) as a part of comprehensive therapy. Enterovirus meningitis developed in children with preexisting persistent Epstein–Barr virus infection (30%) and human herpesvirus 6 infection (53%). Results. Administration of Viferon® reduced the duration of fever by 1.3 times (p < 0.05). Pathogen elimination from cerebrospinal fluid was observed in 80.0% of patients receiving Viferon® and in 46.7% of controls (p < 0.05). During convalescence, the T cell count came back to normal only in children receiving Viferon®. Conclusion. Viferon® stimulates helper T cells thereby regulating humoral immune reactions. Key words: herpesviruses, children, interferons, enterovirus infection
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