ГЕНЕТИЧЕСКИЕ МАРКЕРЫ ПСИХОЛОГИЧЕСКОГО БЛАГОПОЛУЧИЯ В ВОЕННО-ПРОФЕССИОНАЛЬНОЙ ДЕЯТЕЛЬНОСТИ ВОЕННОСЛУЖАЩИХ АРКТИЧЕСКОЙ ЗОНЫ

Abstract

The study aims to determine features of the emotional state, to assess the severity of depression and anxiety symptoms in military personnel who undergo military service under extreme climate conditions, to detect the association between gene polymorphisms, and to identify their most favorable combination. The L. A. Kurgansky and T. A. Nemchin method was used to assess the stress level; the hospital anxiety and depression scale was used to assess the level of anxiety and depression; the level of personality neuroticism was assessed with the express diagnosis scale developed by the staff at the V. M. Bekhterev State Medical Research Center of Psychiatry and Neurology. Real-time genotyping of servicemen’s genome DNA samples was carried out on a DTprime amplifier. One-way analysis of variance assessed the significance of differences in mean values of qualitative indicators with a normal distribution between three independent groups. The Kraskel-Wallis test assessed variables, whose distribution differed from normal. The assessment of independent factors affecting dependent binary groups was conducted with logistic regression. With more than two groups, assessment was conducted with polynomial logistic regression. The results are demonstrated as a relation of chances with a 95 % confidence interval. Poisson regression was used for discrete variables, with results demonstrated as a related risk with a 95 % confidence interval. The method of psychological and psychiatric screening allowed determining the prevalence of an average level of emotional well-being of military personnel who undergo military service in Arctic zone, as well as their genotypes suitable for such service: genotype T/T of the ACTN3 gene (rs1815739), genotype C/C of the HIF1A gene (rs11549465), genotype T/T of the LIPC gene (rs1532085), and genotype G/G of the BDNF gene (rs6265).