Abstract
Objective of the Review: To analyse the contemporary idea of the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in cardiovascular comorbidities. Key Points. Adverse class-mediated side effects of NSAIDs complicate the use of these drugs in cardiovascular pathologies. Moderate Nimesulide selectivity is a cause of low risks of blood pressure destabilization, vascular catastrophes (acute myocardial infarction, stroke), other thrombotic complications recorded in clinical trials. Conclusion. These characteristics allow recommending Nimesulide in cardiovascular comorbidities, especially in situations where the use of other NSAIDs is limited due to side effects and contraindications. Keywords: nonsteroidal anti-inflammatory drugs, cyclooxygenase, comorbidity, cardiovascular diseases, Nimesulide, Nise.
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