Abstract
The effect of preventive administration of the complex phytopreparation "tetraphyton" has been studied in experiments on rats. Tetraphyton developed on the base of Tibetan formula is the dry extract derived from species of plant material: roots of Inula helenium L., roots of Zingiber officinale Roscoe, fruits of Elletaria cardamomum (L.) Maton, offshoots of Caragana spinosa (L.) Wall. ex Hornem., characterized for the content of phenolic compounds, flavonoids, terpenoids. The preventive course introduction of tetraphyton in a dose 100 mg/kg for 7 days before experiment increases the potential for physical performance, increasing overall physical endurance against a background of intense physical exertion by 73 % (p < 0.05), prevents fatigue. It is shown that increase in the physical performance of rats in the experimental group is due to increase in the efficiency of the energy supply system in skeletal muscles and myocardium: a significant increase in the content of ATP (by 13 % and 2.5 times); decrease in lactate and pyruvate content (by 33 and 30 %; p < 0.05); increased glycogen content in the liver by 23 %, blood glucose by 19 %. The increase in catalase, SOD, and gSh levels (5 %, 19 %, 79 %; p < 0.05) indicates an increase in the power of the antioxidant defense of the organism and causes the cytoprotective effect of tetraphyton, confirmed by a decrease in fermentemia (lactate dehydrogenase, kreatinphosphokinase - 49 % and 43 %; p < 0.05). The main molecular-cellular mechanisms of the actoprotective action of the phytoadaptogen is the inhibition of the lipid peroxidation of cell membranes and a significant increase in the capacity of the endogenous antioxidant enzyme system that promotes the preservation of the integrity of skeletal muscles and the myocardium. This is due to the presence of phenolic compounds in the chemical composition that have direct antiradical action and increase the power endogenous antioxidant system.
Highlights
В опытах на лабораторных животных проведена оценка влияния многокомпонентного растительного средства с условным названием «тетрафитон» на физическую выносливость в тесте вынужденного плавания
Tetraphyton developed on the base of Tibetan formula is the dry extract derived from species of plant material: roots of Inula helenium L., roots of Zingiber officinale Roscoe, fruits of Elletaria cardamomum (L.) Maton, offshoots of Caragana spinosa (L.) Wall. ex Hornem., characterized for the content of phenolic compounds, flavonoids, terpenoids
The preventive course introduction of tetraphyton in a dose 100 mg/kg for 7 days before experiment increases the potential for physical performance, increasing overall physical endurance against a background of intense physical exertion by 73 % (p ≤ 0.05), prevents fatigue
Summary
Алексеева Э.А. 1, Димитров О.Г. 2, Шантанова Л.Н. 2, Муруев Б.А. 2, Торопова А.А. 2. «Тетрафитон» представляет собой сухой экстракт, полученный из четырёх видов растительного сырья: корневищ Inula helenium L., Zingiber officinale Roscoe, плодов Elletaria cardamomum (L.) Maton. The main molecular-cellular mechanisms of the actoprotective action of the phytoadaptogen is the inhibition of the lipid peroxidation of cell membranes and a significant increase in the capacity of the endogenous antioxidant enzyme system that promotes the preservation of the integrity of skeletal muscles and the myocardium This is due to the presence of phenolic compounds in the chemical composition that have direct antiradical action and increase the power endogenous antioxidant system. Ранее проведёнными фармакологическими исследованиями установлена выраженная актопротекторная активность фитомикса с условным названием «кардекаим» на основе сырья четырёх видов растений: корневищ Inula helenium L., Zingiber officinale Roscoe, плодов Elletaria cardamomum (L.) Maton., побегов Caragana jubata, – превосходящая по действию препараты элеутерококка и женьшеня [9]. Целью работы являлось определение влияния многокомпонентного растительного средства «тетрафитон» на физическую выносливость белых крыс в условиях запредельных нагрузок
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