Abstract
The effects of chloral hydrate anesthesia on the level of systolic blood pressure (SBP), heart rate (HR), mortality, neurological status, and behavior were investigated in aged Wistar rats using the set of tests light-dark chamber, field, beam-walking. It is shown that in 24-month-old rats, the intraperitoneal injection of chloral hydrate at a dose of 400 mg/kg leads to a decrease in SBP, an increase in heart rate. It increased the neurological deficit, mortality, inhibition of exploratory activity, psycho-emotional stress in the open field test. Experimental studies using aged Wistar rats to introduce new protective drugs in clinical practice require careful selection of anesthesia drugs and a set of tests to evaluate behavioral reactions.
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