Нормотермическая и гипертермическая интраперитонеальная перфузионная химиотерапия диссеминированного рака яичника в эксперименте

Abstract

Relevance The search and development of effective regimens of normothermic and hyperthermic intraperitoneal chemoperfusion (IPEC and HIPEC) in experiment will allow implementing the technology into clinical practice to treat patients with advanced ovarian cancer and therefore increase their survival. The purpose of the study The development of preclinical model of normo- and hyperthermic chemoperfusion treatment of advanced ovarian cancer and assessment of efficiency of alkylating cytostatics at their intraperitoneal chemoperfusion administration. Materials and methods The study was carried out in 295 Vistar female rats with ovarian cancer which was inoculated intraperitoneally. IPEC and HIPEC were performed with antitumor drugs cisplatin and dioxadet in maximum tolerated doses (MTD) which were 5−20 times higher than those for the standard intraperitoneal administration of the drugs. Antitumor effects of the treatment were estimated in increase of median survival time (MST). Results and their discussion Hyperthermic intraperitoneal perfusion (HIPEP) with saline solution showed significant antitumor activity comparable to effects of intraperitoneal administration of cisplatin and dioxadet. HIPEC with the drugs resulted in larger number of side effects compared to IPEC. Potentiation of antitumor effect of dioxadet and hyperthermia was achieved for HIPEC with dioxadet, where increase in MST of rats was the greatest among all experimental groups – 444% compared to the control group (p=0.038). Conclusion The developed experimental technology of IPEC and HIPEC is recommended for testing of different cytostatic drugs and new methods of intraperitoneal chemoperfusion treatment of malignancies affecting peritoneum.