Характеристика ліпідного обміну в підлітків з ожирінням та ознаками метаболічного синдрому

Abstract

One of the most important issues of modern medical science is the metabolic syndrome, the origins of which begin in childhood and adolescence. Diagnostic criterias for metabolic syndrome for children are developed by the International Diabetes Federation (IDF, 2007). It is known that atherogenic dyslipidemia is one of the main and early criteria of the metabolic syndrome and plays an important role in the pathogenesis of the atherosclerotic process and associated cardiovascular diseases. Due to the insufficient amount of information about the nature of dyslipidemia in adolescents and the possibilities for its correction and prevention, the study of this problem is relevant. Purpose - to study the characteristics of lipid profile in adolescents with obesity and signs of metabolic syndrome. Materials and methods. We examined 200 obese patients aged 14-18 years, who were divided into two groups: with and without metabolic syndrome according to current recommendations. The control group consisted of 30 adolescents with normal body weight of a similar age. To achieve the goal, all adolescents underwent a comprehensive examination with a focus on the lipid profile of blood using standardized methods in accordance with the IFCC recommendations on a Cormay Multi semi-automatic photometer. The level of β-lipoproteins in blood serum was determined by the turbidimetric method of Burstein M. and Samaille F. Results. In adolescents with metabolic syndrome, signs of atherogenic dyslipidemia were found, manifested in the form of elevated levels of triglycerides, low and very low density lipoprotein cholesterol, β-lipoproteins, a tendency to decrease high density lipoprotein cholesterol. Reliable correlations were established in the lipid profile of the blood of the examined, and reliable relationships were determined between the indicators of atherogenic dyslipidemia and anthropometric measurements, which indicates an increased risk of lipid metabolic disturbances in individuals with abdominal obesity. Conclusions. The results will help to focus the attention of practitioners regarding atherogenic dyslipidemia in adolescents with obesity and signs of metabolic syndrome, as well as contribute to early therapeutic intervention and prevention of consequences. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the author. Key words: adolescents, metabolic syndrome, dyslipidemia.