Abstract
The survey of the literature data and authors’ research on molecular-cell mechanisms of the osteoinductive effect of calcium-phosphate compounds and their importance during fracture healing. The usage of titanium implants containing calcium-phosphate and hydroxyapatite covering leads to structural transformation of the bony tissue in the interstitial gap and activation of the reparative processes. This activities correlate with the changes in expression of morphogenetic and apoptotic factors in different stages of the reparative osteogenesis. Reparative effect of the calcium-phosphate compounds can be estimated as a sum of cambial activity CD44-reactive mesenchymal stem cells and secondary fracture spread – the apoptosis of the cells of bone regenerate. The interaction of these processes in each stage of bone healing provides bone morphogenetic proteins, vascular endothelial growth factor and transformative growth-factor-β. Current issues of the metal alloy with bioresorbable covering for the long bones healing are discussed.
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