Окислительный стресс и гемореология у больных инфарктом миокарда с сахарным диабетом 2 типа

Abstract

This paper highlights the influence of the intensity of the oxidative stress on hemorheology parameters
 in complicated and uncomplicated acute myocardial infarction in patients with diabetes type 2. The
 study was performed by analyzing the results of examination and treatment of 66 patients, men aged 65,6 ± 5,8
 years old, suffering from coronary heart disease with clinical manifestations of acute myocardial infarction and
 concomitant diabetes type 2. Depending on the presence of acute heart failure patients were divided into 2
 groups. 1st group consisted of 34 patients with myocardial infarction without complications, Group 2 - 32 patients
 who have myocardial infarction complicated by acute heart failure (II-III class classification T.Killip).
 Condition pro- and antioxidant systems were evaluated for 3 days by determining in the blood of patients
 diene conjugates, malonic dialdehyde, α-tocopherol, ceruloplasmin, calculated coefficient of oxidative stress.
 The rheological properties blood evaluated by the blood coagulation time, the hematocrit, amount the fibrinogen
 in the blood, and blood plasma viscosity, red blood cells deformability index, the aggregation of red blood cells
 and thrombocytes. The values obtained were compared with data from 32 healthy donors.
 It is revealed that the development of congestive heart failure in acute myocardial infarction in patients
 with diabetes type 2 is accompanied by activation of lipid peroxidation (LPO) by maintaining a high level of
 primary lipid peroxidation products. Insufficient activity of antioxidant defense can limit oxidative processes,
 and leads to their further growth. The damaging effect of lipid peroxidation in the cell membranes is reflected in violation of aggregation and blood viscosity indexes.