ТЕОРЕТИЧЕСКОЕ ОБОСНОВАНИЕ, РАЗРАБОТКА СОСТАВА И ИЗУЧЕНИЕ ПРОТИВО-ВОСПАЛИТЕЛЬНОЙ АКТИВНОСТИ ГЕЛЕЙ С СО2-ЭКСТРАКТОМ ABIES SIBIRICA

Abstract

Abstract. Extraction using liquefied gases, in particular carbon dioxide, has a number of well-known advantages and prospects. It is noteworthy that the CO2-extract of Siberian fir thus obtained differs from traditional extracts in terms of technological and biological properties. The gel obtained on the basis of this extract for external use has a pronounced anti-inflammatory and antimicrobial effect. Purposeful and theoretically grounded selection of gel bases led to such gelling agents as methylcellulose, carbopol-940 and polyeth-ylene oxide-1500. Subsequent biological tests showed that 1% gel with CO2-extract of fir based on carbo-pol-940 can be used in dermatology as an anti-inflammatory and wound healing agent (abrasions, bruises and mild burns). The use of liquefied gases as an extractant significantly reduces the time spent on extrac-tion, makes it possible to obtain dehydrated, completely natural extracts, eliminates the effect of high tem-peratures at the concentration stage and improves the quality of the final products. It is also important that in the process of extraction in carbon dioxide, most of the known microbial cells cease their vital activity. In the technological process, neither preservatives nor stabilizers are added to the extracts, therefore they are of low toxicity and can be successfully used in children's and geriatric practice. Extracts have a wide therapeutic spectrum, do not lead to negative consequences and are not addictive with long-term use.