Abstract
Cardiovascular diseases are still the leading causes of death in the world. Atherosclerosis of the arteries of the lower extremities is one of them. A risk factor for the development of atherosclerosis is diabetes mellitus, particularly type 2. The fact that these diseases are systemic and multifactorial is generally recognized. Considering the progress of genetics and gene therapy in recent decades, the search for genes responsible for the development of both lower limb atherosclerosis and type 2 diabetes mellitus is relevant. Their identification can probably help to improve the prognosis of the course of these diseases, personalize the system of prevention and treatment. Homocysteine is an amino acid involved in the pathogenesis of both obliterative atherosclerosis and diabetes mellitus. In this context, folate cycle genes, which play a major role in the development of hyperhomocysteinemia, are of particular interest.
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