Abstract
Objective. To study the efficacy of surface-enhanced Raman spectroscopy of blood plasma in the diagnosis of endometrial pathologies. Materials and methods. Plasma samples from 48 women aged 22 to 63 years were examined using surface-enhanced Raman spectroscopy (polyp: 31 samples, hyperplasia: 10 samples, control: 7 samples). Three spectra were recorded for each sample. The analysis of spectral characteristics of the colloidal medium with dried samples was performed on a test bench consisting of a spectrometric system (RamanLife RL785, FOTON-BIO LLC, Russia) based on a CCD detector and microscope (ADF U300, ADF, China). A silver substrate based on dried silver colloid was used as SERS substrate to realize the effect of Raman signal amplification. Results. The accuracy of differentiating endometrial polyps from the control group and endometrial hyperplasia for the calibration and validation sets was 83% and 81%, respectively (sensitivity: 62%, specificity: 91% for the validation set). The accuracy of differentiating the control group from endometrial hyperplasia and polyp was 64% and 71%, and hyperplasia from the control group and polyp was 64% and 67%, respectively. Conclusion. This study demonstrated the possibility of using Raman spectroscopy in clinical practice to diagnose endometrial pathologies. Key words: hyperplasia, discriminant analysis, projection to latent structures, blood plasma, surface-enhanced Raman spectroscopy, polyp
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
