Abstract
The antinociceptive activity of new derivatives of α-cyanothioacetamide was evaluated in the formalin test, which reflects an acute inflammatory reaction. For the study, a standard model of an acute inflammatory reaction was used: laboratory animals were subplantarly injected with 0.1 ml of 5% formalin (algogen) into the right hind limb. The α-cyanothioacetamide samples studied were injected intragastrically at 1 ml at a dose of 5 mg/kg 1.5 hours before the experiment. The comparison drug was chosen as Analgin JSC "Pharmstandard" at a dose of 7 mg/kg. For one hour after injection, the number of pain reactions was recorded according to the method of 4 types of behavioral response. We have identified the potential antinociceptive activity of new derivatives of α-cyanothioacetamide, which allows them to be used for a detailed study.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
