Abstract
Key words: flavonoids, hydroxycinnamic acids, herb, achillea setacea Waldst. et Kit., a. submillefolium Klok. et Krytzka, HPLC. Plants of the genus achillea L. are rich in polyphenolic compounds, which play an important role in the prevention of chronic diseases, slowing down aging processes as well as reducing the risk of cardiovascular and neurodegenerative diseases. The most studied is the chemical composition of Achillea millefolium, while other plant species growing in Ukraine have not been studied enough. The aim of our work was researching the qualitative and quantitative composition of polyphenolic compounds in the herb of achillea setacea Waldst. et Kit. and a. submillefolium Klok. et Krytzka. Materials and methods. The shredded air-dry raw materials of Achillea submillefolium Klok. et Krytzka and A. setacea Waldst. et Kit. were used for the study. Thin-layer chromatography was used to identify flavonoids and hydroxycoric acids. The method of high-performance liquid chromatography was used to separate the sum of polyphenolic compounds into individual components. Results and discussion. Qualitative identification of flavonoids and hydroxycinnamic substances by TLC revealed the presence of chlorogenic and neochlorogenic acids, luteolin in both species, and rutin in a. setacea Waldst. et Kit. The content of hydroxycinnamic acids and flavonoid compounds were determined by HPLC method. The predominant components are luteolin-7,3’-di-O-β-D- glycoside, neochlorogenic acid, rutin, apigenin-7,4’-di-O- glucopyranoside. The obtained results make to predict the antioxidant, antibacterial and antifungal activity of the extracts of the studied plants.
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