Клинико-микробиологическая характеристика течения респираторных инфекций у детей с различным прививочным анамнезом

Abstract

Objective. To determine the clinical and microbiological features of the duration of respiratory infections in children with different vaccination history. Patients and methods. Children (106 people) with inflammatory diseases of the respiratory tract were examined, 64 of them were vaccinated in accordance, 42 people were vaccinated with deviations from the National schedule of vaccinations. The oropharyngeal discharge and saliva were examined in PCR to detect RNA and DNA of viral and bacterial pathogens. We used test systems produced by the Federal State Budgetary Institution of Rospotrebnadzor and “Vector-Best”. Results. It was found that the number of children with recurrent respiratory tract infections among vaccinated with deviations from the vaccination schedule and unvaccinated (59.5 ± 7.6%) is 2 times higher (p ≤ 0.01) than among vaccinated (28.1 ± 5.6%). No concomitant clinical syndromes were detected in 68.8 ± 5.8% of vaccinated children, which significantly (p ≤ 0.001) differed from a similar indicator (35.7 ± 7.4%) in children with impaired vaccination schedule and unvaccinated. Differences in the frequency of occurrence of pathogen genomes were found among pathogens of viral infections only with respect to representatives of the Herpesviridae, whose DNA was more often detected in children with the disrupted vaccination schedule and unvaccinated (p < 0.05). DNA of methicillin-resistant coagulase-negative Staphylococcus spp. more often (p < 0.05) was detected in children with violations of the vaccination schedule and unvaccinated (30.1 ± 7.0%), and more often in association with herpesviruses. Conclusion. The presented data indicate an important stimulating effect on the children's body of vaccines included in the National schedule of Vaccinations. This indicates the need for vaccination of children, especially with recurrent respiratory diseases and an unfavorable premorbid background. Key words: viral and bacterial pathogens, children, vaccination history, respiratory infections