Гиперурикемия как фактор риска развития осложнений метаболического синдрома у пациентов пожилого возраста

Abstract

Uric acid is involved in most of the pathogenetic mechanisms of the metabolic syndrome. Hyperuricemia plays a significant role in the processes of inflammation, endothelial dysfunction, atherogenesis, and insulin resistance. The results of a large number of studies demonstrate that an increase in the level of uric acid, especially in elderly patients with cardiovascular diseases, leads to higher mortality rates and is its independent predictor. Hyperuricemia is an important factor in assessing the risk of the development and severity of obesity-associated complications, which should be taken into account when choosing treatment options for this category of patients. Early diagnosis of hyperuricemia might be one of the methods for controlling the risk of development of cardiovascular diseases, disorders of carbohydrate and lipid metabolism in patients who are over 60 years old. The choice of antihypertensive drugs in metabolic syndrome should take into account their effect on serum uric acid levels. Since the role of asymptomatic hyperuricemia as an independent predictor of cardiovascular disease and mortality in patients with a high overall cardiovascular risk is generally recognized, it is necessary to improve the available methods of management of the existing metabolic disorders in further clinical studies. Measures are needed that are aimed at lifestyle correction and body weight normalization, which can have a tangible therapeutic effect, and they should be recommended before medication administration. Key words: hyperuricemia, diet therapy, insulin resistance, metabolic syndrome, obesity, old age