Abstract
This study examined the chemical profile and antioxidant effects of Juniperus rigida Sieb. et. Zucc. (JS) fruit extract. The carbohydrate content was high, and leucine, lysine, and histidine were the major total essential amino acid components in the JS fruit extract. The major organic acids were malic acid, citric acid, and tartaric acid. Saturated fatty acids (stearic acid, capric acid, heptadecanoic acid, and tricosanoic acid) and monounsaturated fatty acids (cis-11-eicosenoic acid and palmitoleic acid) were detected in the JS fruit extract. The order of mineral content was Ca>K>Mg. The total polyphenol and flavonoid contents were 84.22 mg TAE/g and 136.24 mg RE/g, respectively. Furthermore, the JS fruit extract (0.05, 0.1, 0.2 mg/mL) had a growth inhibitory effect on MCF-7 and HCC38 breast cancer cells; the effect was greater in the MCF-7 cell line than in the HCC38 cell line. The present study showed that JS fruit extracts play a major role in the antioxidant and anti-cancer effects in breast cancer cells.
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