Натрийуретический пептид при ожирении и неалкогольной жировой болезни печени в молодом возрасте

Abstract

The purpose — to study the relationship of increased natriuretic peptide (NUP) with obesity and non-alcoholic fatty liver disease (NAFLD) in young people. Material and methods. 142 patients, including 74 men and 68 women aged Me = 35 [31–39] years, were examined at the consulting and diagnostic center of the Aviastroiyelny district of Kazan. The study design is an observational clinical case-control study based on the criterion of constitutional obesity. A questionnaire was conducted, as well as a clinical examination with anthropometry, bioimpedance measurement, assessment of the level of N-terminal cerebral natriuretic peptide (NUP), ultrasound examination of the liver with detection of NAFLD, echocardiography. The indices of liver steatosis Non-Alcoholic Fatty Liver Disease – Liver Fat Score (NAFLD-LFS), Hepatic Steatosis Index (HSI) and Triglyceride and glucose Index (TyG) were calculated. The data is processed in IBM SPSS Statistics 26. Results. According to ultrasound data, NAFLD was found in 12.6% of the examined patients. Patients with NAFLD and exogenous constitutional obesity tended to have a higher incidence of elevated levels of NUP when compared with the group of obese people without NAFLD. The prognostic model results showed that NAFLD, HSI index > 36, as well as female gender were associated with an increase in NUP. At the same time, obesity and male gender reduced the likelihood of NUP increase. Conclusion. NAFLD and obesity have a multidirectional effect on the likelihood of NUP increase among young people without diabetes mellitus and cardiovascular diseases. The presence of NAFLD is associated with an increase in NUP, while exogenous constitutional obesity reduces the likelihood of NUP increase.