Abstract
Isolation studies model such spaceflight factors as a prolonged stay in a closed environment, psycho-emotional strain, continuous microbial exchange, unusual diet and hygiene. We analyzed the data about vaginal and cervical microflora from female participants in two isolation studies without means of dysbiosis prevention. According to results of the investigation, isolation conditions affect the microbial status of the vagina and cervical channel, as the number of opportunistic species, both facultative and strict anaerobes, increases and the number of protective species decreases. These shifts in microbiota of the lower genital tract imply high risks of dysbiotic disorders and the need to develop preventive means, including probiotic substances based on autologic strains of vaginal lactic acid bacilli.
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