Abstract
Pharmacokinetics of azithromycin in the blood plasma of pigs was investigated following single intramuscular administration of Zitrex as a part of the preclinical studies. Zitrex, containing 100 mg/ml of azithromycin as the active substance, was administered to 6 piglets once intramuscularly in the neck area at the dose of 1 ml/20 kg, which corresponds to 5 mg/kg of azithromycin. In 1; 3; 6; 9; 12; 18; 24; 36; 48; 60; 72; 84 and 96 hours following Zitrex administration blood samples were collected and azithromycin concentrations in blood plasma were analyzed by high performance liquid chromatography using a fluorescent detection. The pharmacokinetic profile of azitromicin in blood plasma of pigs was established. The data obtained allow designating the tested substance as a «long-lived» compound.
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