Abstract
We studied the response of trigger systems in healthy volunteers living in areas with different levels of air pollution. We determined that particles with the size of 800 microns and higher of relatively favorable region, particles with the size of less than 50 microns dominated in the air of the unfavorable area, among which there were the most hazardous to health amounts of microparticles - from 200 to 300 nm. Microparticles of unfavorable area causes the development of oxidative modifications of proteins and DNA contributing to the change of leukocyte potential energy. The increase in total antioxidant activity and response of thiol-disulfide system (the increase in thioredoxin, glutathione with a stable reductase level] maintains a balance of oxidation and antioxidant processes contributing to protection of the cellular and subcellular structures against considerable oxidative damage.
Highlights
THE FORMATION OF OXIDATIVE DISORDERS IN THE POPULATION OF VLADIVOSTOK UNDER THE INFLUENCE OF ATMOSPHERIC MICROPARTICLES
We studied the response of trigger systems in healthy volunteers living in areas with different levels of air pollution
We determined that particles with the size of 800 microns and higher of relatively favorable region, particles with the size of less than 50 microns dominated in the air of the unfavorable area, among which there were the most hazardous to health amounts of microparticles – from 200 to 300 nm
Summary
ФОРМИРОВАНИЕ ОКСИДАТИВНЫХ НАРУШЕНИЙ, ВЫЗВАННЫХ ВОЗДЕЙСТВИЕМ МИКРОЧАСТИЦ АТМОСФЕРНЫХ ВЗВЕСЕЙ У НАСЕЛЕНИЯ Г. Изучено влияние микрочастиц атмосферного воздуха на развитие окислительного стресса у здоровых жителей города. Исследованы содержание и состав микрочастиц в атмосферном воздухе г. Формирование окислительного стресса, индуцированного микрочастицами, вызывает повреждение макромолекул и снижение энергетического статуса клеток. We studied the response of trigger systems in healthy volunteers living in areas with different levels of air pollution. Основным механизмом токсического действия МЧ является их способность индуцировать выработку активных форм кислорода (АФК), способствующих развитию окислительного стресса [3]. TRX-система, модулируя активность факторов транскрипции и участвуя в регуляции экспрессии провоспалительных цитокинов и апоптоза, играет ключевую роль в защите клеточных структур от окислительного стресса [7]
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