Abstract
У статті висвітлено вплив окремих компонентів метаболічного синдрому: артеріальної гіпертензії, ожиріння й дисліпідемії на функцію нирок при гіпотиреозі, причинно-наслідковий зв’язок між вказаними компонентами й гіпотиреозом та нирковою дисфункцією. Показано, що артеріальна гіпертензія, абдомінальне ожиріння, гіперлептинемія, дисліпідемія є незалежними факторами ризику розвитку порушення функції нирок при гіпотиреозі.
Highlights
International research proves that diabetes mellitus, arterial hypertension (AH), obesity and dyslipidemia, i.e. major components of metabolic syndrome (MS), constitute an independent risk factor for the development of cardiovascular diseases, and of chronic kidney disease (CKD) [1,2,3]
CKD is identified as a risk factor for cardiovascular events; for example — the risk of cardiovascular mortality is 6 times higher with albuminuria threshold exceeding 300 mg/day and 5 times higher if glomerular filtration rate (GFR) decreases to less than 70 ml/min
Stages of CKD are determined according to the level of GFR, rather than that of creatinine, since blood creatinine begins to increase when GFR is half less than its normal value, i.e. hypercreatininemia is observed in case when more than 50 % of nephrons are inactive [6]
Summary
International research proves that diabetes mellitus, arterial hypertension (AH), obesity and dyslipidemia, i.e. major components of metabolic syndrome (MS), constitute an independent risk factor for the development of cardiovascular diseases, and of chronic kidney disease (CKD) [1,2,3]. Most researchers consider hypertension a disease which develops regardless of the presence of hypothyroidism, all of them confirm a positive effect of substitution therapy with thyroid hormonal preparations on the level of blood pressure (BP) [19, 20].
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